Evaluation of eye disorder induced by chemotherapy including S-1

Evaluation of eye disorder induced by chemotherapy including S-1 - EyeDropS study(HGCSG1604)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000027192

Enrollment

180

Registered

2017-06-24

Start date

2018-05-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Histologically confirmed carcinoma in GIC, including esophageal, gastric, colorectal, pancreatic, and biliary cancer. 2) Receives chemotherapy including S-1. 3) Age 20 years or older 4) Written informed consent.

Exclusion criteria

Exclusion criteria: 1) Prior medication of S-1. 2) Continuing the eye drops treatment. 3) Scheduled to have an ophthalmic operation within six months. 4) Lachrymal duct obstruction or more than three points of corner conjunctiva epithelium disorder score.

Design outcomes

Primary

Measure	Time frame
cumulative incidence of epiphora in periods from start of S-1 chemotherapy to 12 weeks after induction S-1	—

Secondary

Measure	Time frame
cumulative incidence of epiphora in overall S-1 chemotherapy periods, the time of outbreak and severity of epiphora, the situation of ophthalmological intervention, ophthalmological changes, risk factors of epiphora, and QOL	—

Countries

Japan

Contacts

Public ContactMasataka Yagisawa

Hokkaido University Hospital Cancer center

yagisawa.m@hotmail.co.jp+81-11-716-1161

Outcome results