Heart Failure
Conditions
Interventions
Group A: Administer carperitide Carperitide is administered in addition to oral diuretic being taken at the time of registration to this study, and continued for 48 hours. Carperitide is initiated
Sponsors
Gunma Prefectural Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who meet all of the following criteria are included in this study. 1.The patients who are hospitalized due to the exacerbation of cardiac heart failure. 2.Patients whose systolic blood pressure on admission is between 100mmHg to 140mmHg. 3.Patients who are at least 75 years old when he or she agreed to this study. 4.Patients, including patient's custody, spouse, guardian or similar subject, who agreed within 6 hours after hospital admission.
Exclusion criteria
Exclusion criteria: Patients who fall into one or more of the following criteria are excluded from participating in the study. 1.Dialysis patients. 2.Patients with no urine production:<100ml/day. 3.Patients who do not feel thirsty or have difficulty to take water orally. 4.Patients who have already used tolvaptan before hospitalized. 5.Patients who have an allergic past history to tolvaptan. 6.Patients who use ASV within 48 hours after registration. 7.Patients who take SGLT2 inhibitors within 48 hours after registration. 8.Patients who are assessed to be inappropriate for the study by study investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days before starting cardiac rehabilitation (group therapy). | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement and amount and percentage change from the baseline of each observation point for the following parameters: 1.Urine volume 2.Exercise tolerance measured during cardiopulmonary exercise testing 3.Body weight 4.Vital signs and general blood/urine tests 5.Special blood/urine tests 6.Incidence of abnormal electrolyte levels(Na and K) 7.The cost of heart failure treatment until the start of cardiac rehabilitation. 8.Number of days until the improvement of SpO2(>97%) 9.Number of patients who need the rescue remedy (Systolic blood pressure<90mmHg or use of cathecholamine with in 48hours) 10.The ratio of continuous outpatient rehabilitation. | — |
Countries
Japan
Contacts
Public ContactTaisuke Nakade
Gunma Prefectural Cardiovascular Center Department of Cardiology
Outcome results
None listed