Impact of a 12-week non-energy-restricted diet with n-3 fatty acid supplementation and moderate physical activity on biochemical parameters, body composition, and physical fitness in women with pre-obesity. Three-arm randomised trial.

Impact of a 12-week non-energy-restricted diet with n-3 fatty acid supplementation and moderate physical activity on biochemical parameters, body composition, and physical fitness in women with pre-obesity. Three-arm randomised trial. - N-3 fatty acid supplementation in combination with life style modification

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027168

Enrollment

Registered

2017-04-27

Start date

2014-03-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

overweight women

Interventions

Lifestyle modification (in intervened groups: a) with lifestyle modification and b)group with lifestyle modification and n-3 fatty acids supplementation): Lifestyle modification consisted of a 3-month

self-tailored&quot

program of defined and supervised physical activity and diet. Physical activity included 30 minutes of continuous walking from the total minimum amount of 10.000 steps a day (monitored by pedometers)

and decrease intake of saturated and trans fat, salt, sugars, and red meat. They were instructed to limit intake of vegetable oils with polyunsaturated n-6 fatty acids, and exclude highly processed fo

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 20-60 years of age, women, fulfilling two of three criteria for pre-obesity (overweight), that is Body Mass Index (BMI) in the range of 25-29.9 kgm-2, waist circumference equal or higher than 80 cm, body fat measured by bioelectrical impedance analysis (BIA) equal or higher than 25 percent of total body weight. Ability and willingness to adhere to the protocol and signed and dated written informed consent obtained before the study

Exclusion criteria

Exclusion criteria: pregnancy and lactation, smoking, long-term medication, history of cardiovascular, endocrine, and metabolic diseases, cancer, significant recent weight gain or loss (more than 5 percent of total body weight within the past 3 months)

Design outcomes

Primary

Measure	Time frame
Body weight, Body Mass Index, waist circumference, bioelectrical impedance analysis, spiroergometry (VO2 max.), 24-hours dietary recall, adiponectin, leptin, insulin, follistatin, brain-derived neurotrophic factor, leukocyte inhibitory factor, tumor necrosis factor alpha, interleukin 6, interleukin 8, vitamin D.	—

Countries

Europe

Contacts

Public ContactAssociate Professor Dana Mullerova M.D., Ph.D.

Faculty of Medicine in Pilsen, Charles University, Czech Republic Department of Public Health and Preventive Medicine

dana.mullerova@lfp.cuni.cz00420377593191

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026