Does the response in urine output to a small dose of furosemide predict organ failure after achievement of negative fluid balance in acute respiratory failure ?

Does the response in urine output to a small dose of furosemide predict organ failure after achievement of negative fluid balance in acute respiratory failure ? - Furosemide stress test to predict tolerance to negative fluid balance

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000027134

Enrollment

Registered

2017-04-27

Start date

2016-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute respiratory failure

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Mechanically ventilated patients who have been endotracheally intubated for respiratory failure with hemodynamic stability were included

Exclusion criteria

Exclusion criteria: (1) baseline estimated glomerular filtration rate (eGFR) <30 ml/minute/1.73m2; (2) known pregnancy; (3) evidence of obstructive uropathy (for example, hydro-ureter) (4) patients with allergy or known sensitivity to loop diuretics (5) achievement of AKIN stage III criteria; (6) evidence of volume depletion at the time of furosemide administration

Design outcomes

Primary

Measure	Time frame
Poor tolerance of negative fluid balance in 24 hours Poor tolerance of negative fluid balance was evaluated by the development of hypotension, or the need for fluid expansion, or the need for vasopressors. When NFB was induced by furosemide, acute kidney injury was also considered as a criterion of poor tolerance.	—

Countries

Japan

Contacts

Public ContactJUN KATAOKA

Tokyo Bay Urayasu Ichikawa Medical Center Department of Critical Care Medicine

rdcyc910@yahoo.co.jp047-351-3101

Outcome results