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Ocular circulation changes and intraocular pressure reduction induced by ripasudil or dorzolamido/timolol fixed combination added to prostaglandin agalogues in primary open angle glaucoma

Ocular circulation changes and intraocular pressure reduction induced by ripasudil or dorzolamido/timolol fixed combination added to prostaglandin agalogues in primary open angle glaucoma - Ocular circulation changes and intraocular pressure reduction induced by ripasudil or dorzolamido/timolol fixed combination added to prostaglandin agalogues in primary open angle glaucoma

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000027047
Enrollment
20
Registered
2017-05-09
Start date
2017-08-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma

Interventions

Adding topical ripasudil or cosopt ophtalmic solution to prostaglandin analogue. Using each eye drop for 2 months

Sponsors

Department of Ophthalmology, Toho University Ohashi Medical Center.
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Subjects who met all of the following inclusion criteria are included:best-corrected visual acuity of at least 15/25,spherical refractie errors between -6.00 and +6.00 diopters,and arefractive cylindrical error within +/-2.00D

Exclusion criteria

Exclusion criteria: Subjects who aren't satisfied with inclusion criteria.Subjects who have a history of intraocular surgery except for cataract. Subjects who have a clinically significant retina-choroidal disease,vitreous disease,or corneal disease.Subjects who have high systolic blood pressure over 150mmHg or high diastolic pressure over 90mmHg at rest.Subjects who are taking Ca blocker,or alpha-1 blocker,or beta-1 blocker,or Sildenafil.

Design outcomes

Primary

MeasureTime frame
Assessment of mean blur rate measured by laser speckle flowgraphy and vessel density measured by OCT angio graphy in optic nerve head and macula after adding each topical.

Countries

Japan

Contacts

Public ContactKyoko Ishida

Department of Ophthalmology, Toho University Ohashi Medical Center. Department of Ophthalmology

kyoko.ish@gmail.com03-3468-1251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026