Mild reflux esophagitis
Conditions
Interventions
On-demand therapy using 20-mg vonoprazan (24 and 52 weeks)
Sponsors
Nippon Medical School Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 20 years old, and younger than 80 years old. 2. Both males and females 3. Outpatients 4. Patients who have been diagnosed with mild reflux esophagitis (Grade A or B by the Los Angeles classification), maintain remission by standard-dose oral PPI therapy, are satisfied with the treatment, and have an esophageal hiatal hernia smaller than 2 cm 5. Patients who understood study, and provided written consent based on their own will
Exclusion criteria
Exclusion criteria: 1. Liver and kidney dysfunction 2. Allergy to many kind of drugs 3. Pregnant or possibility of being pregnant, and those who are breastfeeding. 4. Participation in another study within the last 4 months. 5. Study participation decided to be contraindicated by the person in charge. 6. Administration of atazanavir sulfate and rilpivirin hydrochloride. 7. Severe allergy to or history of complications on using vonoprazan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.The endoscopic remission rate and overall satisfaction level after 24- and 52-week on-demand therapy 2. The gastrin level before breakfast and the number of 20-mg vonoprazan tablets taken before and after on-demand therapy (24 and 52 weeks) | — |
Countries
Japan
Contacts
Public ContactMariko Umezawa
Nippon Medical School Hospital Department of Gastroenterology
Outcome results
None listed