Prospective, multicenter study for prediction of therapeutic effect of FOLFIRINOX with analyzing 5FU metabolism to aim the tailor-made therapy for unresectable pancreatic cancer.

Prospective, multicenter study for prediction of therapeutic effect of FOLFIRINOX with analyzing 5FU metabolism to aim the tailor-made therapy for unresectable pancreatic cancer. - Prospective, multicenter study for prediction of therapeutic effect of FOLFIRINOX with analyzing 5FU metabolism to aim the tailor-made therapy for unresectable pancreatic cancer.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000027009

Enrollment

Registered

2017-04-16

Start date

2017-04-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pancreatic cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Histologically or cytologically proved pancreatic adenocarcinoma or adenosquamous carcinoma Age 20-80 years ECOG Performance Status (PS) 0-1 Unresectable pancreatic cancer with measurable lesion according to RECIST ver.1.1 Meets the following criteria within 7days before enrollment absolute neutrophil count<2,000/uL, platelet count<100,000/uL, hemoglobin<9 g,/dL, white blood cell count<10,000/uL, bilirubin < ULN, AST and ALT < 2.5 X ULN, Written informed consent

Exclusion criteria

Exclusion criteria: Homotype of UGT1A1 genotype including *28/*28, *6/*6 and*6/*28 Evident pleural effusion, ascites, pericardial effusion or peritoneal metastasis on CT before enrollment Pulmonary fibrosis or interstitial pneumonia Watery stool within 3 days before enrollment Uncontrolled diabetes mellitus Any serious complication

Design outcomes

Primary

Measure	Time frame
progression free survival	—

Countries

Japan

Contacts

Public ContactShigeru Horiguchi

Okayama university hospital Department of general medicine

horiguchis@gmail.com086-235-7221

Outcome results