Retrospective study of the prognosis of Japanese patients with pulmonary hypertension

Retrospective study of the prognosis of Japanese patients with pulmonary hypertension - Retrospective study of the prognosis of Japanese patients with pulmonary hypertension

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000026985

Enrollment

300

Registered

2017-04-15

Start date

2017-04-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary hypertension

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with pulmonary hypertension who have or had been treated in our hospital and satisfy the following criteria. 1) pulmonary hypertension Group 1, pulmonary arterial hypertension (PAH) Group 4, chronic thromboembolic pulmonary hypertension (CTEPH) 2) ages 16 and above 3) WHO functional class 1 and above

Exclusion criteria

Exclusion criteria: Since this study is a retrospective study, we investigate all the cases which satisfy the inclusion criteria.

Design outcomes

Primary

Measure	Time frame
In this study, primary end point is composite endpoint which meets the either criteria of the followings. 1) all cause death (cardiovascular death/ non-cardiovascular death) 2) worsening of pulmonary hypertension worsening of pulmonary hypertension is defined as a condition which meets both of the criteria as follows: a) worsening of the symptom due to pulmonary hypertension, b) necessity of adding oral pulmonary vasodilators, intravenous inotropes or intravenous vasopressors. worsening of the symptom due to pulmonary hypertension is defined as a condition which meets either criteria as follows: a) worsening of WHO functional class, b) worsening of the symptom due to rright heart failure and diuretics dose needs to be increased. 3) Necessity of any treatment as follows: atrial septostomy, lung transplantation, initiation of treatment with IV or SC prostanoids.	—

Measure

Time frame

In this study, primary end point is composite endpoint which meets the either criteria of the followings. 1) all cause death (cardiovascular death/ non-cardiovascular death) 2) worsening of pulmonary hypertension worsening of pulmonary hypertension is defined as a condition which meets both of the criteria as follows: a) worsening of the symptom due to pulmonary hypertension, b) necessity of adding oral pulmonary vasodilators, intravenous inotropes or intravenous vasopressors. worsening of the symptom due to pulmonary hypertension is defined as a condition which meets either criteria as follows: a) worsening of WHO functional class, b) worsening of the symptom due to rright heart failure and diuretics dose needs to be increased. 3) Necessity of any treatment as follows: atrial septostomy, lung transplantation, initiation of treatment with IV or SC prostanoids.

—

Secondary

Measure	Time frame
1) death due to PH or hospitalization due to worsening of PH 2) worsening of the symptom due to pulmonary hypertension 3) change of hemodynamic parameters 4) change of the symptom using questionare. (PM-ADL8/SF-8/HADS) 5) change of laboratory examination 6) change of echocardiographic parameters 7) change of pulmonary function test 8) tapering or withdrawal of home oxygen therapy	—

Countries

Japan

Contacts

Public ContactYoshihisa Nakano

Nagoya University Graduate School of Medicine Department of Cardiology

middlefield0608@med.nagoya-u.ac.jp052-744-2138

Outcome results