In this study, we investigate drug hypersensitivity using a definitive diagnosis algorithm (modified Mirakian R. Clin Exp Allergy. 2009 Jan
Conditions
Interventions
Blood test, skin prick test and provocation test.
Sponsors
Department of Pediatrics, Ehime University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Individuals with diagnosed and suspected drug hypersensitivity in Ehime University Hospital.
Exclusion criteria
Exclusion criteria: * Objectives without written informed concern. * Objectives judged as ineligible by the chief of the study. * Objectives with and suspected fetal and severe systemic drug reactions. * Objectives without healthy skin region to be performed skin tests. * Objectives without the skin region untreated by steroid ointments to be performed skin tests. * Objectives with intravenous steroid within 1 month. * Objectives with intravenous immunosuppressive agent within 1 month. * Objectives with oral antiallergic drug within 1 week. * Objectives with oral antihistamine within 1 week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our definitive diagnosis algorithm has 4 steps. Primary endpoints are 1) skin prick test is positive in Step 2, 2) provocation test is positive in Step 3, and 3) significant associations between HLA types and kind of drug that has positive reaction by provocation test in Step 2. | — |
Countries
Japan
Contacts
Public ContactMiwa Shinohara
Ehime University Hospital Department of Pediatrics
Outcome results
None listed