Tricuspid annular plane systolic excursion / Left Ventricular Outflow Tract Velocity Time Integral (TAPSE / LVOT VTI) ratio to predict fluid responsiveness in critically ill patients who have spontaneously breathing and assisted with mechanical ventilation.

Tricuspid annular plane systolic excursion / Left Ventricular Outflow Tract Velocity Time Integral (TAPSE / LVOT VTI) ratio to predict fluid responsiveness in critically ill patients who have spontaneously breathing and assisted with mechanical ventilation. - TAPSE/LVOT-VTI ratio and fluid responsiveness in patients on mechanical ventilation who have spontaneous breathing

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000026946

Enrollment

100

Registered

2017-04-11

Start date

2016-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically ill patients who are mechanically ventilated and have spontaneous breathing

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Mechanically ventilated patients who have spontaneous breathing with at least one of the clinical findings of tissue hypoperfusion for whom the attending physicians decided to conduct rapid fluid challenge test in the absence of contraindication for fluid infusion will be include in this study. Clinical signs of tissue hypoperfusion are defined as follows. a) Systolic blood pressure < 90 mm Hg (or a decrease < 50 mm Hg in previously hypertensive patients) or the need for vasopressive drugs (dopamine or norepinephrine); b) urine output < 0.5 mL/kg/hr for in 2 hrs; c) tachycardia (heart rate > 100/min); or d) presence of skin mottling.

Exclusion criteria

Exclusion criteria: The patients with suspected acute coronary syndrome, known coronary artery disease or patients after cardiac open surgery within a month will be excluded. The patients whose TAPSE and LVOT VTI cannot be obtained on transthoracic echocardiogram (TTE) will be also excluded.

Design outcomes

Primary

Measure	Time frame
Fluid responsiveness	—

Countries

Japan

Contacts

Public ContactYasuhiro Norisue

Tokyo Bay Urayasu Ichikawa Medical Center Pulmonary and Critical Care Medicine

norisue.yasuhiro@gmail.com080-5895-9696

Outcome results