The effect of an amino acid on the hand-foot syndrome induced by sorafenib administration for hepatocellular carcinoma

The effect of an amino acid on the hand-foot syndrome induced by sorafenib administration for hepatocellular carcinoma - The effect of an amino acid on the hand-foot syndrome induced by sorafenib administration

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000026898

Enrollment

Registered

2017-04-20

Start date

2017-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand-foot syndrome

Interventions

Uptake of an amino acid supplement

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients planned to be hospitalized for sorafenib administration for HCC. Patients equal or over 20 years old.

Exclusion criteria

Exclusion criteria: Patients who has food allergy to fish. Patients who cannot eat and drink by themselves. Patients who have been taking dried-bonito broth to alleviate adverse effects caused by sorafenib.

Design outcomes

Primary

Measure	Time frame
Occurrence of Hand-foot syndrome	—

Secondary

Measure	Time frame
Blood flow in the hands and feet. Changes in appetite, sleep and fatigue obtained by interviews.	—

Countries

Japan

Contacts

Public Contactsame as above

same as above same as above

ethics@adm.niigata-u.ac.jp0252272207

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026