Clostridium difficile enteritis
Conditions
Interventions
Diluted faeces of relatives within the third parents are once administered into patien'
s colon using the lower gastrointestinal endoscope
Sponsors
Osaka City University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Clostridium difficile or Clostridium difficile antigen were detected from feces 2) Patients who did not cure Clostridium difficile enteritis with traditional antibiotic therapy or had a high probability of recurrence of Clostridium difficile enteritis 3) Age at the time of obtaining informed consent is greater than or equal to 20 years. 4) Patients who can eat foods orally. 5) Patients who write document consent by their own will after our explain.
Exclusion criteria
Exclusion criteria: 1) Patients who have malignant tumors or serious systemic diseases (central nervous disease, psychiatric disorders) or poor general condition 2) Patients who already have gastrointestinal disease.(i.e. Crohn's disease, intestinal tuberculosis) 3) Patients who have swallowing disorder 4) Patients who have severe liver disease (AST or ALT >=100 IU/L) 5) Patients who have severe kidney disease (serum Cre >= 2.0 mg/dL) 6) Pregnant or lactating women 7) Patients who are judged by doctors as inappropriate as subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure rate of Clostridium difficile enteritis within 6 months Incidence of adverse events due to fecal microbiota transplantation (FMT) | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of intestinal microflora before and after fecal microbiota transplantation therapy | — |
Countries
Japan
Contacts
Public ContactYuji Nadatani
Osaka City University Graduate School of Medicine Department of Gastroenterology
Outcome results
None listed