Epidural analgesia: a randomized clinical trial comparing loss of resistance to saline versus low volume of air

Epidural analgesia: a randomized clinical trial comparing loss of resistance to saline versus low volume of air - Epidural loss of resistance with saline and air

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000026851

Enrollment

208

Registered

2017-04-03

Start date

2009-06-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labor

Interventions

Loss of resistance at epidural space was achieved with a syringe filled with less than 3 mL of air. Once epidural space was located, 3 mL of saline was injected through the needle. loss of resistance

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Laboring term patients aged 18-40 years requiring epidural analgesia.

Exclusion criteria

Exclusion criteria: Patients classified as American Society of Anesthesiology physical status more than 3, presence of allergies to local anesthetics, idiosyncratic reactions to opioids, contraindication for neuraxial analgesia or hemodynamic instability.

Design outcomes

Primary

Measure	Time frame
Successful epidural catheter placement	—

Secondary

Measure	Time frame
pain control, maternal satisfaction, characteristics of blockade, and side effects	—

Countries

South America

Contacts

Public ContactLeopoldo E. Ferrer

Fundacion Santa Fe de Bogota Anesthesia Department

lfanesthesia@gmail.com+5716030303

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026