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A pilot study to evaluate the effect of colchicine treatment on NSAID-induced small intestinal damage

A pilot study to evaluate the effect of colchicine treatment on NSAID-induced small intestinal damage - Effect of colchicine on NSAID-induced small intestinal damage (a pilot study)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000026828
Enrollment
10
Registered
2017-04-03
Start date
2017-04-03
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NSAID-induced small intestinal damage

Interventions

Prescribe one tablet of colchicine (0.5 mg) twice a day for 8 weeks.

Sponsors

Department of Gastroenterology, Osaka City University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) More than 20 years old 2) Possible oral administration 3) Written informed consent obtained 4) Patients with category 3 (more than 5 erosions) or 4 (large erosion or ulcer) defined by Graham DY (Graham DY et al. Clin Gastroenterol Hepatol, 2005)

Exclusion criteria

Exclusion criteria: 1) Malignant tumor or severe systemic disease (CNS disase or psychiatric disease) 2) Crohns disease, intestinal tuberculosis, or known gastrointestinal stricture 3) Unable to swallow the video capsule 4) Pacemaker 5) Concomitant use of antibiotics 6) Severe liver disease 7) Severe renal disease 8) Hypersensitivity for colchicine 9) Pregnant or lactating women 10) Active small bowel bleeding (Patients with endoscopic hemostasis or intravascular embolization can be enrolled.) 11) Inadequate judged by PI

Design outcomes

Primary

MeasureTime frame
Complete healing rate of small intestinal erosions and ulcers in 8 weeks of colchicine administration—

Countries

Japan

Contacts

Public ContactKoji Otani

Osaka City University Graduate School of Medicine Department of Gastroenterology

kojiotani@med.osaka-cu.ac.jp06-6645-3811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026