Analysis of toxic metals in hair in dry eye patients

Analysis of toxic metals in hair in dry eye patients - Toxic metals in dry eye

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000026772

Enrollment

Registered

2017-04-01

Start date

2017-04-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We entry the people who meet all conditions below (No.1-4) as dry eye group. And we entry the people who meet conditions (No.1-3) without dry eye disease (DED) as control group. 1. Those aged 40 and over, who gained informed consent of the person himself / herself voluntarily. 2. Those without systemic diseases affecting wound healing such as eye disease and diabetes. 3. Those without a history of corneal and conjunctival surgery within the past 1 year 4. Those diagnosed definite dry eye disease by Japanese DED diagnostic criteria. Diagnosis was established according to the Japanese DED diagnostic criteria, as follows; (1) presence of dry eye symptoms; (2) a.presence of qualitative or b.quantitative disturbance of the tear film in 1 or both eyes (a.Shirmer test <= 5 mm or b.Tear Break Up Time <= 5 seconds); and (3) presence of conjunctivocorneal epithelial damage (total staining score => 3 points) in 1 or both eyes. The presence of all 3 criteria was necessary for a definite diagnosis of DED.

Exclusion criteria

Exclusion criteria: People who meet one of the following conditions are excluded from both dry eye group and control group. 1.Those which can not obtain informed consent for ophthalmic examination. 2.Those that can not obtain informed consent for hair collection 3. Those taking supplements such as vitamin supplements 4. Those having a history of receiving corneal conjunctival surgery within the past one year 5. Those who have cataracts above age appropriate

Design outcomes

Primary

Measure	Time frame
Harmful metal volume in patients' hair	—

Secondary

Measure	Time frame
Clinical dry eye evaluation factors, Schirmer test, Tear Break Up Time, corneal staining score, subjective symptoms	—

Countries

Japan

Contacts

Public ContactYuichi Uchino

Keio University School of Medicine Department of Ophthalmology

hmpgx653@yahoo.co.jp+81-3-3353-1211

Outcome results