Bronchial asthma with allergic rhinitis caused by house dust mite
Conditions
Interventions
None listed
Sponsors
National Hospital Organization Mie National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Bronchial asthma with allergic rhinitis with disease duration of more than 1 year 2. Sensitization to HDM (specific IgE by ImmunoCAP is greater than or equal to class 2) 3. Positive nasal challenge test to house dust allergen 4. Bronchial asthma as follows; a. Mild to moderate severity, not in acute exacerbation b. FEV1 is greater than or equal to 70% of predicted value c. Reversible respiratory symptoms d. Negative specific IgE (class 0 or 1) to dog, cat, Alternaria, and Aspergillus 5. Be willing to receive medication therapy or allergen immunotherapy for bronchial asthma with allergic rhinitis
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding female 2. Patients with sino-nasal disease that might confound accurate determination of the outcomes of the study 3. Patients with severe asthma 4. Smoker or pet keeper 5. Patients with episode of life-threatening treatment-related adverse event 6. Patients with malignant disease or severe systemic disease which affect immune system 7. Patients who cannot receive sublingual immunotherapy by other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in symptoms and medication for allergic rhinitis and asthma by treatment with medicine or sublingual immunotherapy for 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in allergic response in nasal mucosa and skin prick test 2. Change in allergic parameters in peripheral blood 3. Compliance of sublingual immunotherapy 4. Safety (adverse event) | — |
Countries
Japan
Contacts
Public ContactSatoko Usui
National Hospital Organization Mie National Hospital Department of Otorhinolaryngology
Outcome results
None listed