Healthy adults
Conditions
Interventions
Ingestion of amino acid (400 mg/day) for 7 days
Ingestion of placebo for 7 days
Sponsors
Waseda University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Subject received an explanation for this study and gave written informed consent. (2) Subject is healthy and has no chronic disease. (3) Melatonin in saliva can be detectable. (4) Subject must be admitted to this study by the supervisor doctor.
Exclusion criteria
Exclusion criteria: (1) Subject receives treatment, or always uses medicines or quasi-drugs. (2) Subject is expected to use medicine during this study. (3) Subject is or has been serious diseases, thyroid gland disease, adrenal gland disease, or metabolic disorder. (4) Subject is or has been diseases related to sleep. (5) Subject has been diagnosed with xerostomia or has xerostomia symptoms. (6) Subject is or has been diagnosed with the drug or alchol dependence. (7) Subject has the possibility of drug and/or food allergy. (8) Subject is predict to occurred to have life events, which may affect their mental conditions, during this study. (9) Subject has a plan to participate in other study during this study. (10) Subject or his/her family work for a company on manufacturing or selling health foods or foods with function claims. (11) Subject can not sleep during night because of shift work or other reasons. (12) His/her native language is not Japanese. (13) Subject is judged as unsuitable for the study by pre test questionnaire. (14) Subject has a plan to become pregnant during the current study or are pregnant or lactating. (15) Subject has a considerable difference in results of motion sensor and pre-questionaires. (16) Subject has values significantly deviated from the reference range in body measurement values declared beforehand (17) Subject is judged inadequateness on this study by subject background questionnaire. (18) Subject has a plan to travel abroad during two weeks before this study starts and during this study. (19) Subject usually consumes food with functional claims and/or supplement which may affect melatonin secretion. (20) Subject is restricted intake of amino acid because he/she has been diagnosed with genetically deficient in metabolic enzyme. (21) Subject is judged inadequateness on this study by the supervisor doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melatonin concentration in saliva | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortisol concentration in saliva | — |
Countries
Japan
Contacts
Public ContactAtsushi Haraguchi
Waseda University Graduate School of Advanced Science and Engineering
Outcome results
None listed