Healthy adults
Conditions
Interventions
Apply the formulation including an active ingredient to the one side of cheek and the placebo to other side of cheek twice a day for 4 weeks
Sponsors
Kao Corporation
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy males
Exclusion criteria
Exclusion criteria: -Subjects with cutaneous symptoms of atopic dermatitis -Subjects undergoing to the hospital with cardiovascular disease (high blood pressure, heart disease) or within one month after going to hospital. -Subjects who takes medical drugs or supplements (antihypertensive, antiarrhythmic, vitamin E etc.) which may have an influence on the results -Subjects who has the habit of smoking -Subjects participation in another clinical study accompanied by topical application of formulations and tape stripping to the sites to be studied within the past one month -Subjects deemed inappropriate to participate in this study by the principle investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of water content, transepidermal water loss, blood flow, skin color, visual score and texture before and after the topical application for 4weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of cell morphology and the composition of stratum corneum before and after the topical application for 4 weeks. | — |
Countries
Japan
Contacts
Public ContactTakatoshi Murase
Kao Corporation R&D -Core Technology-Biological Science Research
Outcome results
None listed