colorectal cancer
Conditions
Interventions
chemotherapy : FOLFOXIRI
Sponsors
Osaka Medical College Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Histologically confirmed CRC that is not a candidate for curative surginal resection 2)the lower edge of tumor location is Rb-P 3)diagnosed as cT2N1-3N0 or cT3/4N0-3M0 4)there is no lateral lympha node metastasis 5)Age 20-74 6)Psrformance status:0-1 7)Adequate organ functiont 8)Written informed consent prior to sutudy-specific screening procedure
Exclusion criteria
Exclusion criteria: 1)Requires continuous treatment with systtematic steroids 2)History of other malignancy with a disease-free interval<1years(other than curatively treated cutaneous basal cell carcinoma,curatively treated carcinoma in situ of the cervix,and gastroenterological cancer confirmed to be cured by endoscopic mucosal resection) 3)Active infections Pr evious palliative radiation therapy for bone metastasis or brain metastasis within 2 weeks 4)HBs antigen positive 5)Uncontrolled diarrhea,unstable angia,Uncontrolled diabetes mellitus 6)Serious complications 7)grade1 of neuropathy 8)Pregnant or lactating females,and males and fenales unwilling to use contraception 9)Psychiatric disability that would preclude study compliance 10)Otherwise determined by the investigator to be unsuitable for participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease control rate: DCR | — |
Secondary
| Measure | Time frame |
|---|---|
| Response Rate:RR,Progression free survival:PFS,Overall survival:OS,Time to Treatment Failure:TTF,Safety(the rate of Grade3/4toxicity) | — |
Countries
Japan
Contacts
Public ContactTetsuji Terasawa
Osaka Medical College Hospital Chemotherapy Center
Outcome results
None listed