cirrhosis
Conditions
Interventions
Comparative randomized trial between 2 groups:only BCAA
Comparative randomized trial between 2 groups:BCAA+Vitamin D
Sponsors
nippon medical chiba hokusoh hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Decompensated cirrhosis with hypoalbuminemia
Exclusion criteria
Exclusion criteria: Patient with inborn branch chain amino acid metabolic derangement Hepatic encephalopathy more than 3 Total bilirubin value >3 mg/dl patien with decrease of the protein composition ability in the liver The patient allergic to milk The patient who has the medical history of the hyperesthesia to BCAA medicine The patient who is nursing and pregnant Patient with uncotrolled HCC or other malignant tumor Uncontrolled heart failure patient Uncontrolled hypertension or diabetes Patient with Chronic renal failure Patient of hypercalcemia Patient with hyperthyroidism Patient who already takes other vitamin D Patien who takes the drug that combination with the vitamin D preparation is contraindicated Patient with acute liver failure Patient who were judged unsuitable by test responsibility doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skeletal muscle mass, grip, bone density | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective symptoms/objective symptom Performance status Mental symptom Side effect | — |
Countries
Japan
Contacts
Public ContactTomomi Okubo
Nippon Medical Chiba Hokusoh Hospital Gastroenterology
Outcome results
None listed