Early and Short-term Use of PCSK9-Inhibitors on Coronary Plaque Stability in Acute Coronary Syndrome

Early and Short-term Use of PCSK9-Inhibitors on Coronary Plaque Stability in Acute Coronary Syndrome - Adage-Joto study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000026516

Enrollment

Registered

2017-03-13

Start date

2017-03-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The acute coronary syndrome patients with dyslipidemia who undewent percutanous coronary intervention.

Interventions

PCSK9 inhibitors per-month for 3months +atrvastatin 20mg/day atrvastatin 20mg/day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)The age is more than 20 years old 2)acute coronary syndrome patients 3)medical history of dyslipidemia 4)LDL-C>70mg after atrvastatin(20mg)treatment 5) to get initial success of Percutanous cotonary intervension(PCI) 6)Existence of fibrous cap with lipid-rich plaque in the non-culprit lesion 7) capable of follow-up OCT at baseline,3month and 9month follow-up

Exclusion criteria

Exclusion criteria: 1) The patients previously used PCSK9 antibody 2)the patient with Hemodialysis and renal insufficiency 3)severe heart failure(NYHA>3) 4)contraindication and intolerance for statin 5)contraindication for PCSK9 antibody 6)Use of other lipid-lowering therapy(ezetimib,DHA,EPA)

Design outcomes

Primary

Measure	Time frame
Change of fibrous cap thickness at 9 month follow-up OCT	—

Secondary

Measure	Time frame
Secondary endpoints included changes in the MFCT from baseline to the 3-month follow-up, percentage change in the MFCT and lipid arc in the region of interests from baseline to the 3- and 9-month follow-ups.	—

Countries

Japan

Contacts

Public ContactHiroki Uehara

Urasoe general hospital cardiovascular center

cardioexpham1225@hotmail.com098-878-0231

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026