Prostate caner
Conditions
Sponsors
Tokyo Metropolitan Police Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Patients must be under these conditions 1) Patients expect to live more than 10 years after the treatment 2) Prostate cancers are diagnosed by biopsies which they receive in our hospital 3) Patients can receive MRI imaging check and the clinical staging before biopsies is T2aN0. 4) PSA was 20.00 ng/ml or less. 5) The computed tomography (CT) of the chest/abdomen/pelvis and bone scintigraphy do not detect metastatic lesions 6) Functions of the main organs are maintained 6-1) Lliver function; AST and ALT is under 3 times the upper limit of the normal range. 6-2) Heart function;there is no severe abnormality in the electrocardiogram or normal it is confirmed that there is no severe abnormalities by the cardiac ultrasound. 6-3) Renal function; estimated GFR is 15 per minute or more. 7) There is no pubic arch interference in the prostate brachytherapy. 8) It is confirmed at least once that a residual volume is 200 ml or less by an ultrasound. 9) The prostate volume is 50 ml or less by the trans rectal ultrasound. 10) We obtain a written Informed consent of the participation of the study. 11) The result of the prostate biopsy was under these conditions 11-1) The biopsy was performed along the parasagittal, peripheral and base areas of the prostate with an interval of 5 mm. The core number of systematic biopsy is 16 or more and MRI/US fusion-guided biopsy was performed. If the volume of the prostate is small ,the base area of the biopsy can be abbreviated. 11-2) The lesions of the cancer detected core are limited in the targeted area by MRI/US fusion biopsy and the surrounding area. 11-3) The lesions of the cancer detected core was limited in the left or right lobe of the prostate. 12) The result of the biopsy meet any of these Gleason scores and the proportion of the cores. 12-1) Gleason score is 3+3 12-2) Gleason score is 3+4 12-3) Gleason score is 4+3 and the proportion of the core is 50 or less.
Exclusion criteria
Exclusion criteria: Patients must not be under these conditions 1) Patients who had past surgical histories of benign prostatic hyperplasia. 2) Patients who had severe mental disorders. 3) Patients who had other active cancers 4) Patients who doctors judge as unsuitable for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recovery periods from urinary dysfunctions after treatments it is assessed after the treatments by using IPSS, OABSS, IIEF5, FACT-P, NIHCPSI 1 month, 3 months and every 3 months afterwards. | — |
Secondary
| Measure | Time frame |
|---|---|
| sexual function assessed by using IIEF5 rectal bleeding | — |
Countries
Japan
Contacts
Public ContactYuji Hakozaki
Tokyo Metropolitan Police Hospital Department of Urology
Outcome results
None listed