Japanese adults who are healthy or regularly see a doctor
Conditions
Interventions
Duration: 4 weeks Test Material: Nutrient-rich liquid food Dosage: Drink 1 pack (125 mL) for a day before breakfast
Duration: 4 weeks Test Material: Orange juice Dosage: Drink 1 pack (125 mL) fo
Sponsors
ORTHOMEDICO Inc.
Seishin-kai Medical Association Inc, Takara Medical Clinic.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Japanese adults, who is 65 years and more, are aware of daily fatigue 2. Priority selection is made in the order of II: warning zone, III: observation zone, and IV: safety zone, in immunological grade at baseline *However, V (sufficiently high) and I (critical zone) are excluded
Exclusion criteria
Exclusion criteria: 1. Those who have the medical history or under the treatment of malignant tumor 2. Those who have the medical history or under the treatment of autoimmune disease 3. Those who have the medical history or under the treatment of inflammatory bowel disease 4. Those who are currently hospitalized 5. Those who use or take "Foods for Specified Health Uses" and "Foods with Functional Claims" in daily 6. Those who eat Natto, yogurt, and food and beverage including lactic acid bacteria in daily 7. Those who are smokers 8. Those who take anti-allergic drugs 9. Currently taking supplements 10. Those who are allergic to medicines and/or the test food related products 11. Those who are pregnant, breast-feeding, and plan to become a pregnant 12. Those who had participated another clinical test for three months when you signed the informed consent form for this trial 13. Others considered as inappropriate for the study by the physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Scoring of immunological vigor *Assess at 0 and 4 weeks after consuming | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Immunity test T lymphocyte age, Immunological age, T cells, CD4+T cells / CD8+T cells ratio, naive T cells, naive T cells / memory T cells ratio, B cells, NK cells, CD8+CD28+T cells, T-cell proliferation index, CD4+T cells, CD8+T cells, memory T cells *Assess at 0 and 4 weeks after consuming 2. Subjective symptoms a. The Japanese version of Constipation Assessment Scale MT version (CAS-MT) b. Bristol Stool Scale c. Bowel movement diary d. The Likert scale method *Above a, b, and d, assess at 0 and 4 weeks after consuming *Above c, record when defecating 3. Saliva test Salivary immunoglobulin A (sIgA) *Assess at 0 and 4 weeks after consuming 4. Blood test High-sensitive CRP, albumin, prealbumin *Assess at 0 and 4 weeks after consuming 5. Physical examination Muscle mass, grip strength *Assess at 0 and 4 weeks after consuming | — |
Countries
Japan
Contacts
Public ContactNaoko SUZUKI
ORTHOMEDICO Inc. R&D Department
Outcome results
None listed