patients undergoing thoracotomy requiring manipulation intercostals and ribs
Conditions
Interventions
Epidural anesthesia group -Initial medication on the day of surgery: Oral administration of 400mg of celecoxib -Medication 6 hours after administering initial dose: Oral administration of 2
Sponsors
Teikyo University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patients with PS 0 or 1 (ECOG) patients undergoing thoracotomy requiring manipulation intercostals and ribs patients with normal kidney function with creatinine clearance (Ccr, hereafter) >30ml/min patients who have signed the consent form to participate in this study
Exclusion criteria
Exclusion criteria: patients who are taking antidepressants, anti-seizure drugs, and/or opioids prior to surgery patients with serious complications (such as uncontrollable heart, lung, liver or kidney disease, and diabetes) patients with a history of angioedema female patients who are pregnant, nursing, or might be pregnant (voluntary) patients who are problematic in receiving epidural anesthesia (such as patients with spinal deformity and patients undergoing treatment with anticoagulants) patients considered unsuitable for the study by a primary physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score (NRS) on the first postoperative day (1 POD NRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score (NRS) on the third and fifth postoperative day (3, 5 POD NRS) Frequency of analgesic drug use for pain control Sleep disorder score on the first, third, and fifth postoperative day Occurrence rate and severity of adverse effects Time periods of anesthesia in preparation for and during surgery | — |
Countries
Japan
Contacts
Public ContactNoriyuki Matsutani
Teikyo University School of Medicine Surgery
Outcome results
None listed