Effect of antioxidant supplement TwendeeX on prevention of dementia

Effect of antioxidant supplement TwendeeX on prevention of dementia - Effect of TwendeeX on prevention of dementia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000026268

Enrollment

400

Registered

2017-02-23

Start date

2017-06-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild cognitive impairment post stroke

Interventions

TwendeeX, 3 tablets at one time, at once a day, for 12 months TwendeeX placebo, 3 tablets at one time, at once a day, for 12 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: mild cognitive impairment (memory complaint, CDR=0.5, and 23<MMSE) post stroke patinets with normal cognition or mild cognitive impairment (20<MMSE)

Exclusion criteria

Exclusion criteria: dementia due to diffuse Lewy body disease, frontotemporal lobe dementia, Huntington's disease, idiopathic normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, cotricobasal degeneration, multiple system atrophy, encephalitis, meningitis, head trauma patients with major depression, bipolar disorder, alcoholism, drug dependence, or serious disorder.

Design outcomes

Primary

Measure	Time frame
effect of TwendeeX on cognition (MMSE, HDS-R, and FAB) compared with Twendeex placebo at 6 months and 12 months	—

Countries

Japan

Contacts

Public ContactRyuta Morihara

Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University Departments of Neurology

p2k07ll9@okayama-u.ac.jp086-235-7365

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026