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Efficacy of regenerative surgical therapy using Er: YAG laser for peri-implantitis: a randomized controlled clinical trial

Efficacy of regenerative surgical therapy using Er: YAG laser for peri-implantitis: a randomized controlled clinical trial - Efficacy of regenerative surgical therapy using Er: YAG laser for peri-implantitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000026229
Enrollment
24
Registered
2017-02-20
Start date
2016-01-10
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implantitis

Interventions

Test group (N=12) Decontamination of affected implant and debridement of granulation tissue around peri-implantitis are made using Er: YAG laser. Control group (N=12) Decontamination of affected

Sponsors

Niigata University
Lead Sponsor
1. Department of Periodontology, Asahi University, School of Dentistry 2. Department of Periodontology, Osaka Dental University
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Person who obtained written informed consent. 2.One study implant have at least 2 sites of probing pocket depth (PPD) greater than 5 mm with bleeding on probing (BOP) and more than 3 mm bone loss.

Exclusion criteria

Exclusion criteria: 1.Persons who had received non-surgical peri-implant therapy within the previous 3 months 2.Persons who had received surgical peri-implant therapy within the previous 6 months 3.Persons who had taken systemic antibiotics or anti-inflammatory drugs within 3 months before experiment 4.Acute periodontal burden on the study implant and the adjacent natural tooth 5.Smoker 6.Persons who had severe systemic diseases 7.Persons who are pregnant or suspected to be pregnant 8.Pacemaker or any other systemic conditions that might be affected by the Er: YAG laser treatment 9.Persons who are judged to be unqualified for this study subjects by investigators.

Design outcomes

Primary

MeasureTime frame
The changes of LPS level before and after the decontamination of affected implant surface.

Secondary

MeasureTime frame
Probing pocket depth Bone level Bacterial counts in subgingival plaque Biomarker level in peri-implant crevicular fluid

Countries

Japan

Contacts

Public ContactYasutaka Komatsu

Niigata University Medical & Dental Hospital

komatsu@dent.niigata-u.ac.jp025-227-2871

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026