Treatment-resistant depression
Conditions
Interventions
Transcranial magnetic stimulation, dorsolateral prefrontal cortex, 4 weeks, 10 Hz, 100-120% MT (motor threshold), 4 sec, 3000 pulsed/day, 5 days/week
Sponsors
Teikyo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Diagnosed as major depression by DSM-5 Larger than 14 in the score of HAMD 17 Less than three years in the period of the most recent depressive episode Treatment-resistant in the present depressive episode
Exclusion criteria
Exclusion criteria: History of psychotic episode, bipolar disorder, obsessive-compulsive disorder, PTSD, or eating disorder History of treatment of ECT, TMS, VNS, DBS, or tDCS Pregnancy History of convulsive disorder including epilepsy History of neurological or organic brain disease Diagnosed as drug or alcohol dependence Magnetic substance in a body including pace-maker, cochlear implant, or intracranial clip Having severe state of diseases of endocrine or metabolic system Having severe level of suicide idea Treated with the medicines which taper the convulsion thresholds
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of depressive symptoms from the start point to eight weeks later | — |
Countries
Japan
Contacts
Public ContactMamoru Tochigi
Teikyo University School of Medicine Department of Neuropsychiatry
Outcome results
None listed