Exploratory study of optimal conditions of non-invasive brain stimulation for intractable pain

Exploratory study of optimal conditions of non-invasive brain stimulation for intractable pain - Exploratory study of optimal conditions of non-invasive brain stimulation for intractable pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025975

Enrollment

Registered

2017-03-01

Start date

2017-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intractable pain

Interventions

Active rTMS, condition 1 single session Active rTMS, condition 2 single session Active rTMS, condition 3 single session Sham rTMS single session Active tDCS single session Sham tDCS single sessi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients with intractable pain for 6 months or longer 2)Patients with 30mm or more in VAS at baseline 3)Patients with insufficient pain relief, despite receiving drugs for pain, or a history of using drugs for pain 4)Patients with an informed consent given

Exclusion criteria

Exclusion criteria: 1)Patients with dementia (MMSE=<24) 2)Patients with severe aphasia or higher brain dysfunction 3)Patients with a major psychiatric disease 4)Patients with a desire for suicide 5)Patients with a history of epileptic attacks 6)Patients with an implantable cardiac stimulator 7)Patients with an implantable deep brain stimulation devices 8)Patients with an implanted metal in their heads, except for titanium products 9)Pregnant patients 10)Patients who cannot write questionaires 11)Patients without ability of agreements 12)Patients receiving other clinical trials or studies within 6 months before agreements 13)Patients who are considered unsuitable for this clinical trial by a principal or sub investigator 14)Patients with a scalp lesion on the stimulation site (tDCS)

Design outcomes

Primary

Measure	Time frame
Pain reduction in VAS Pain reduction in NRS	—

Secondary

Measure	Time frame
Frequency and duration of shooting pain, if a subject has a shooting pain Pain reduction in SF-MPQ 2 (Short form of McGill pain questionnaire 2) PGIC (Patient global impression of change) Improvement in PDAS (Pain Disability Assessment Scale) Improvement in EQ-5D Improvement in PCS (Pain Catastrophizing Scale) Improvement in HADS (Hospital Anxiety and Depression Scale) Change in BDI-II	—

Countries

Japan

Contacts

Public ContactKoichi Hosomi

Osaka University Department of Neuromodulation and Neurosurgery

k-hosomi@nsurg.med.osaka-u.ac.jp+81-6-6210-8435

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026