Which is the best long-acting insulin to reduce hypoclycemia ? Comparison of Insulin glargine 300 U/ml vs. Insulin degludec vs. Insulin glargine 100 U/ml using FreeStyle Libre Pro: randomised triple crossover study

Which is the best long-acting insulin to reduce hypoclycemia ? Comparison of Insulin glargine 300 U/ml vs. Insulin degludec vs. Insulin glargine 100 U/ml using FreeStyle Libre Pro: randomised triple crossover study - Comparison of Insulin glargine 300 U/ml vs. Insulin degludec vs. Insulin glargine 100 U/ml using FreeStyle Libre Pro: randomised triple crossover study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025952

Enrollment

Registered

2017-02-01

Start date

2017-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

FreeStyle Libre Pro is worn after admission. Insulin glargine 300 U/ml are evaluated on day 3 and day 4. Then, Insulin degludec are evaluated on day 8 and day 9. Then, Insulin glargine 100 U/ml are e

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: type 2 diabetic patients medicated long-acting insulin for 3 month or longer

Exclusion criteria

Exclusion criteria: severe renal dysfunction (serum creatinine level over 2.0 mg/dL) judged to be unsuitable for participation for medical reasons

Design outcomes

Primary

Measure	Time frame
AOC (<70 mg/dL) for glycemic variability (0:00-6:00, 8:00-24:00, 24:00)	—

Secondary

Measure	Time frame
00:00 to 6:00 percentage of time in hypoglycemic range (<54 mg/dL) mean absolute glucose (MAG) glycemic variability percentage (GVP) mean glucose level (0:00-6:00, 24:00) SD (0:00-6:00, 24:00) coefficient of variation (CV) (0:00-6:00, 24:00) M-value (0:00-6:00, 24:00) MAGE MODD ADRR low blood glucose index (LBGI)	—

Countries

Japan

Contacts

Public ContactSoichi Takeishi

General Inuyamachuo Hospital Department of Diabetes

souichi19811225@yahoo.co.jp0568-62-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026