Changes in blood concentration of antibiotics and development of pharmacokinetic model in cardiovascular surgery

Changes in blood concentration of antibiotics and development of pharmacokinetic model in cardiovascular surgery - Changes in blood concentration of antibiotics and development of pharmacokinetic model in cardiovascular surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000025933

Enrollment

Registered

2017-01-31

Start date

2017-01-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart disease, Thoracic large vessel disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patients scheduled for cardiovascular surgery 2) patients who are able to obtain consent

Exclusion criteria

Exclusion criteria: 1) patients who undergo cardiovascular surgery without both median sternotomy and intrathoracic operation 2) patients of emergency operation 3) patients with dementia or psychiatric disorders 4) female patients during pregnancy or possibly pregnancy 5) patients whom research investigator has determined to be inappropriate

Design outcomes

Primary

Measure	Time frame
Changes in the blood concentration and the proportions exceeding the blood concentrations that are effective in mild / severe infections respectively in cefazolin (CEZ) and vancomycin (VCM)	—

Secondary

Measure	Time frame
1) Evaluation based on PK-PD theory on CEZ and VCM 2) Factors on blood levels of CEZ and VCM 3) development of optimal antibiotic administration model for cardiovascular surgery (CEZ, VCM) 4) Incidence of postoperative infection 5) In-hospital mortality rate, 28th day postoperative mortality rate, 90th postoperative mortality rate 6) Period of stay at ICU, artificial respiration management period 7) Postoperative complications (such as kidney injury)	—

Measure

Time frame

1) Evaluation based on PK-PD theory on CEZ and VCM 2) Factors on blood levels of CEZ and VCM 3) development of optimal antibiotic administration model for cardiovascular surgery (CEZ, VCM) 4) Incidence of postoperative infection 5) In-hospital mortality rate, 28th day postoperative mortality rate, 90th postoperative mortality rate 6) Period of stay at ICU, artificial respiration management period 7) Postoperative complications (such as kidney injury)

—

Countries

Japan

Contacts

Public ContactMasato Nakasone

Tottori University Division of Anesthesiology and Critical Care Medicine

masui@med.tottori-u.ac.jp0859-38-6657

Outcome results