The efficacy of high-dose penicillin G for pneumococcal pneumonia diagnosed based on initial comprehensive assessment at admission: An observational study

The efficacy of high-dose penicillin G for pneumococcal pneumonia diagnosed based on initial comprehensive assessment at admission: An observational study - The efficacy of high-dose penicillin G for pneumococcal pneumonia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000025887

Enrollment

Registered

2017-01-28

Start date

2016-12-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The consecutive patients aged 18 years or older who were admitted to the hospital for pneumococcal pneumonia and who were initially treated with high-dose penicillin G (more than 1.2 million units of penicillin G).

Exclusion criteria

Exclusion criteria: Patients who were treated with high-dose penicillin G as a de-escalation therapy were excluded.

Design outcomes

Primary

Measure	Time frame
Clinical stability until day 6. Clinical stability was defined as a condition in which all the following threshold values were achieved for a 24-hour period: temperature of < 37.2, heart rate of < 100 beats/min, respiratory rate of < 24 breaths/min, systolic blood pressure of > 90 mmHg, and oxygen saturation of > 90% or arterial oxygen partial pressure of > 60 mmHg when the patient was not receiving supplemental oxygen.	—

Measure

Time frame

Clinical stability until day 6. Clinical stability was defined as a condition in which all the following threshold values were achieved for a 24-hour period: temperature of < 37.2, heart rate of < 100 beats/min, respiratory rate of < 24 breaths/min, systolic blood pressure of > 90 mmHg, and oxygen saturation of > 90% or arterial oxygen partial pressure of > 60 mmHg when the patient was not receiving supplemental oxygen.

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Countries

Japan

Contacts

Public ContactJunpei Komagamine

Tochigi Medical Center Internal medicine

jkomagamine@tochigi-mc.jp028-622-5241

Outcome results