Effects of sodium-glucose co-transporter2(SGLT2) inhibitors on left ventricular systolic and/or diastolic dysfunction in Japanese type2 diabetes

Effects of sodium-glucose co-transporter2(SGLT2) inhibitors on left ventricular systolic and/or diastolic dysfunction in Japanese type2 diabetes - Effects of sodium-glucose co-transporter2(SGLT2)inhibitors on left ventricular dysfunction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000025841

Enrollment

Registered

2017-01-25

Start date

2017-01-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type2 diabetic patients with systolic and/or diastolic dysfunction

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1Type2DM patients those who have been treated with the dietary therapy, therapeutic excercise, and diabetec medicene, and whose blood glucose has not been sufficient controlled. 2The patients with left ventricular diastolic or/and systolic dysfunction 320=<age<75 years old

Exclusion criteria

Exclusion criteria: 1patients with type1 diabetes 2Patients with severe infection, perioperative, severe ketosis, severeinjury 3Patients with mild renal dysfunction(sCr>1.5mg/dl) 4Patients with severe heart failure(NYHA class 4) 5Patients with serious hepatic dysfunction 6Patients with mild MR 7Patients with atrial fibrillation 8Patients with risk of dehydration 9Patients with malignancy 10Patients with malnutrition, stavation 11Patients who are pregnant, breastfeeding or may become pregnant 12Patients taking SGLT2I 13Patients who considered not eligible for the study by the attending doctor due to other reasons

Design outcomes

Primary

Measure	Time frame
Left ventricular diastolic function by echocardiography after 52 week with dapaglifrogin (LVMI,E/e',e')	—

Secondary

Measure	Time frame
BNP or pro BNP after 24 week and 52 week with dapaglifrogin Left ventricular systolic function by echocardiography after 52 week with dapaglifrogin	—

Countries

Japan

Contacts

Public ContactJunko Hamai

Kanagawa Cardiovascular and Respiratory Center Department of Endocrinology and Diabetes

femme-de-docilite@hotmail.co.jp045-701-9581

Outcome results