The effects of Lactobacillus reuteri probiotics on peri-implantitis: a randomized placebo-controlled study

The effects of Lactobacillus reuteri probiotics on peri-implantitis: a randomized placebo-controlled study - Probiotics for peri-implantitis patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025813

Enrollment

Registered

2017-01-26

Start date

2016-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

peri-implantitis

Interventions

Subject took one tablet containing L. reuteri probiotics a day for 6 months (intervention group) Subject took one tablet non-containing L. reuteri probiotics a day for 6 months (control group)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: probing pocket depths are more than 4 mm and less than 7 mm bleeding or suppuration on probing (+) marginal bone loss > 2 mm

Exclusion criteria

Exclusion criteria: patients with uncontrolled systematic disease patients who took antibiotics within 3 months pregnant women patients allergic to antibiotics

Design outcomes

Primary

Measure	Time frame
periodontal bacterial count (4wks, 12wks, 24wks after the intake of probiotics )	—

Secondary

Measure	Time frame
probing pocket depth, bleeding on probing, modified gingival index, modified plaque index at 4wks, 12wks, 24wks after the intake of probiotics	—

Countries

Japan

Contacts

Public ContactChihiro Masaki

Kyushu Dental University Department of Oral Reconstruction and Rehabilitation

masaki@kyu-dent.ac.jp093-285-3100

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026