Helicobacter pylori infection
Conditions
Interventions
Vonoprazan 20mg bid Amoxicillin 750mg bid Metronidazole 250mg bid 7 days
Rabeprazole 10mg bid Amoxicillin 750mg bid Metronidazole 250mg bid 7 days
Sponsors
Yokohama City University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A patient who failed first-line eradication therapy with Vonoprazan, Amoxicillin and Clarithromycin. A patient who can do eradication therapy as second time(second-line) in this study. A patient who was diagnosed for Helicobacter pylori infection and failure of first-line eradication by urea breath test or Helicobacter pylori stool antigen test. A patient who can perform urea breath test after 8 weeks from treatment completion. A patient who give a written informed consent.
Exclusion criteria
Exclusion criteria: A patient who has eradication history except triple therapy with Vonoprazan, Amoxicillin and Clarithromycin. Pregnancy or lactation. Past history of allergy for the drugs used in this study. A patient with brain and spinal cord disease. A patient with infectious mononucleosis. Severe liver dysfunction, severe renal dysfunction, severe heart dysfunction. Patient who is disqualified for the study by physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate assessed by urea breath test more than 8 weeks after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety evaluated by side effect questionnaire filled by patients | — |
Countries
Japan
Contacts
Public ContactSoichiro Sue
Yokohama City University Hospital Gastroenterology
Outcome results
None listed