A randomized controlled trial comparing Vonoprazan, Amoxicillin and Metronidazole triple therapy and Vonoprazan, Amoxicillin and Clarithromycin triple therapy as a first-line eradication of Helicobacter pylori

A randomized controlled trial comparing Vonoprazan, Amoxicillin and Metronidazole triple therapy and Vonoprazan, Amoxicillin and Clarithromycin triple therapy as a first-line eradication of Helicobacter pylori - RCT comparing VAM and VAC HP eradication as first-line

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025773

Enrollment

190

Registered

2017-01-22

Start date

2017-01-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection

Interventions

Vonoprazan 20mg bid Amoxicillin 750mg bid Metronidazole 250mg bid 7 days Vonoprazan 20mg bid Amoxicillin 750mg bid Clarithromycin 200mg bid 7 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A patient with Helicobacter pylori infection without history of Helicobacter pylori eradication. A patient without susceptibility testing result of Helicobacter pyori. A patient who can perform urea breath test after 8 weeks from treatment completion. A patient who give a written informed consent.

Exclusion criteria

Exclusion criteria: Pregnancy or lactation. Past history of allergy for the drugs used in this study. A patient with brain and spinal cord disease. A patient with infectious mononucleosis. Severe liver dysfunction, severe renal dysfunction, severe heart dysfunction. Patient who is disqualified for the study by physicians.

Design outcomes

Primary

Measure	Time frame
Eradication rate assessed by urea breath test more than 8 weeks after treatment	—

Secondary

Measure	Time frame
Safety evaluated by side effect questionnaire filled by patients.	—

Countries

Japan

Contacts

Public ContactSoichiro Sue

Yokohama City University Hospital Gastroenterology

ssue@yokohama-cu.ac.jp045-261-5656

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026