Helicobacter pylori infection
Conditions
Interventions
Vonoprazan 20mg bid Amoxicillin 500mg qid Clarithromycin 400mg bid Metronidazole 250mg bid 2 weeks This regimen is used with modification based on susceptibility testing.
Sponsors
Yokohama City University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A patient with Helicobacter pylori infection failed for first, second (one week triple therapy with acid suppressant and amoxicillin and clarithromycin or metronidazole) and sitafloxacin based third line eradication . A patient who was diagnosed for Helicobacter pylori infection by urea breath test or Helicobacter pylori stool antigen test. A patient who can perform urea breath test after 8 weeks from treatment completion. A patient who give a written informed consent.
Exclusion criteria
Exclusion criteria: A patient who don't agree for endoscopy and susceptible testing as own expense medical care before eradication therapy. Past history of allergy or side effect requiring treatment for the drugs used in this study. Pregnancy or lactation. A patient with brain and spinal cord disease. A patient with infectious mononucleosis. Severe liver dysfunction, severe renal dysfunction, severe heart dysfunction. Patients who are disqualified for the study by physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate assessed by urea breath test more than 8 weeks after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety evaluated by side effects questionnaire filled by patients | — |
Countries
Japan
Contacts
Public ContactSoichiro Sue
Yokohama City University Hospital Gastroenterology
Outcome results
None listed