Prevention of Postoperative Atrial Fibrillation after Heart Valve Surgery by L-Carnitine: Study Protocol for An Observational Intervention Study

Prevention of Postoperative Atrial Fibrillation after Heart Valve Surgery by L-Carnitine: Study Protocol for An Observational Intervention Study - Prevention of Postoperative Atrial Fibrillation by L-Carnitine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025737

Enrollment

Registered

2017-01-30

Start date

2017-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart valve diseases

Interventions

The total intervention period will be nine days. L-carnitine (L-Cartin FF oral solution 10%, Otsuka Pharmaceutical Co., Ltd., Tokyo) (3 gm/day) will be administered daily to the patients in three oral

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. They are patients with a diagnosis of heart valve disease necessitating elective surgery under cardiac arrest through median sternotomy with or without coronary artery bypass grafting. 2. They are between 20 and 90 years of age. 3. They are competent and able to give informed consent.

Exclusion criteria

Exclusion criteria: 1. They have a history of atrial fibrillation or flutter before surgery. 2. They have renal failure (serum creatinine > 2.0 mg/dl). 3. They are pregnant. 4. They are lactating.

Design outcomes

Primary

Measure	Time frame
The incidence of atrial fibrillation within seven days after surgery	—

Countries

Japan

Contacts

Public ContactYasushige Shingu

Hokkaido University Graduate School of Medicine Department of Cardiovascular and Thoracic Surgery

shingu@huhp.hokudai.ac.jp011-706-6042

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026