atrial fibrillation
Conditions
Interventions
None listed
Sponsors
Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with NVAF who: 1. are taking an oral anticoagulant at the time of enrollment 2. can undergo a brain magnetic resonance imaging (MRI) at the time of enrollment 3. have provided informed consent in writing 4. are between the ages of 40 and 84 years at the time of enrollment 5. have a Clinical Dementia Rating (CDR) global score of 0 to 0.5 and a Mini-Mental State Examination (MMSE) score of 20 to 30 6. and are accompanied by a study partner (someone who knows how the patient lives)
Exclusion criteria
Exclusion criteria: 1. Patients with valvular atrial fibrillation 2. Patients unable to undergo MRI examination, or MRI cannot be evaluated due to body movement, etc. 3. Patients with dementia with a CDR global score greater than or equal to 1 or MMSE less than 20 4. 6 months or less since occurrence of stroke 5. Less than or equal to 6 years of education 6. Judged by an investigator to be ineligible to participate as a study subject
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in MMSE from time of enrollment until 3 years after enrollment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in Montreal Cognitive Assessment (MoCA) from time of enrollment until 3 years after enrollment 2. Time until occurrence of any death, stroke, or cardiovascular event 3. Change in CDR global score from time of enrollment until 3 years after enrollment 4. Change in Clinical Dementia Rating Sum of Boxes (CDR-SB) score from time of enrollment Time until hemorrhagic or ischemic event | — |
Countries
Japan
Contacts
Public ContactNaoki Saji
Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and G Strawberry Registry Secretariat
Outcome results
None listed