Patients with chronic cough and healthy subjects
Conditions
Interventions
Patients receive the diagnostic and induction therapy for chronic cough.
Sponsors
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Male and female patients with chronic cough and healthy subjects >= 20 years of age are eligible for inclusion. Chronic cough has been defined as "cough lasting longer than 8 weeks as the only symptom and whose cause is not apparent by physiological examination and routine testing such as chest X-ray and spirometry". Chronic cough include atopic cough, cough variant asthma and sinobronchial syndrome. The diagnosis of causative disease have been made by the therapeutic diagonsis.
Exclusion criteria
Exclusion criteria: Key exclusion criteria were: use of histamin H1 receptor antagonist, inhaled/oral/intravenous corticosteroid, leukotriene receptor antagonist, beta2-aganist, theophylline, macroraide, expectorant drug, and proton pump inhibitor; women of childbearing potential or of breast-feeding; mental disorder or psychiatric symptom; several medical conditions prohibiting partitipation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the feasibility for measurement of lipid mediator in exhaled breath condensate of the chronic cough patients and healthy subjects | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the concentration of 5-HETE, 12-HETE, 15-HETE, PGD2, PGE2, PGI2, 6-keto PGF1alpha, LTB4, LTD4 and LTE4 in the exhaled breath condensate among the chronic cough patients and healthy subjects | — |
Countries
Japan
Contacts
Public ContactJohsuke Hara
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University Department of Respiratory Medicine
Outcome results
None listed