Diabetes mellitus and Periodontitis
Conditions
Interventions
Treatment of periodontitis
Sponsors
Shimane University Faculty of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Under treatment for Diabetes Mellitus type 2, or diagnosed by 75g OGTT. 2) Age on the agreement is within 20-80 yeas-old. 3) Data within 60 days fulfill the criteria below: HbA1c>=7.0% (if <70 years-old) HbA1c>=8.0% (if >=70 years-old) 4) Presence of periodontitis 5) Participants give their written consent to join this study.
Exclusion criteria
Exclusion criteria: 1) The number of residual teeth is <12. 2) Received oral therapy within past 3 months. 3) Undergoing insulin therapy. 4) Changed abruptly in HbA1c level >=2% within past 3 months. 5) Current morbidity with acute infection, malignant disease or dementia. 6) Past history of hypersensitivity against Tetracycline antibiotics. 7) Past history of shock against the component of Amoxicillin capsules. 8) Past history of hypersensitivity against the component of Amoxicillin capsules or Penicillin antibiotics. 9) Infected by Infectious mononucleosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| More than 25% of patients whose HbA1c level decreases 0.5% or more after the final treatment (3 months later), compared to that of the basal level. | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c level is compared to that of historical control (past 3 months changes before the treatment). The other parameters (fasting blood sugar, insulin, HOMA-IR, blood pressure, lipids, liver function, urinary protein, changes of the number and species of oral bacteria, gingival index score, gingival bleeding, CRP, IL-6, and TNFalpha) are compared to those of the basal level. | — |
Countries
Japan
Contacts
Public ContactTomii Yuko
Shimane University Faculty of Medicine Clinical Research Center
Outcome results
None listed