Healthy Adult
Conditions
Interventions
Ingestion of milk-derived components and glucosamine for 8 weeks
Ingestion of glucosamine for 8 weeks
Ingestion of placebo for 8 weeks
Sponsors
Jikoukai Medical Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy male and female who are 60 years old and more, and less than 75 years old when taking informed consent. 2. Those who have knee- and waist- pain 3. Those who can come to the designated hospital on scheduled date 4. Those who can write life record correctly 5. Those who understand objectives and protocol of this study with written consent
Exclusion criteria
Exclusion criteria: 1. Patients with OA, RA and/or goat 2. Those who have difficulty to participate in this study because of conditions i.e., liver, kidney, or cardiac disease, breathing, endocrinology, metabolism, nervous, or conscious disorder, diabetes (determined by JDA), and other diseases. 3. Those with history of cardiovascular diseases 4. Those who use medicines, health foods and supplements (including "Food for specified health uses", "Foods with function claims" and "Food with nutrient function claims") constantly, excepting those who can stop them at taking of informed consent. 5. Those who have allergies of test tablets (including dairy product and crustacean) 6. Those who have had bad feeling after blood collection 7. Those who are participating in other tests or who participated in last 4 weeks. 8. Heavy drinker of alcohol and/or heavy smoker 9. Those who have extremely irregular eating and living habits 10. Those who do not agree with the intent of this study explained beforehand 11. Those who are judged as inappropriate for the subject of this test by clinical investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| JKOM, JLEQ, VAS of knee- and waist- pain at rest, walking and stair-climbing, Questionnaires about motion of knee- and waist- joints, Passive range of movement of knee- and waist- joints, 10-m walking (normal- and maximum-speed), Obstacle walking, Ascending and descending stairs, Open-close stepping counts, One-leg standing duration (when eye-opened and -closed) | — |
Secondary
| Measure | Time frame |
|---|---|
| Hyaluronic acid (HA), Cartilage oligomeric matrix protein (COMP), Collagen type II Cleavage (C2C), Procollagen type II C-Propeptide(CP2), C-terminal telopeptides of type II collagen (CTX-2), MMP-3, MP-9, MMP-13, IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, Urine- C-terminal telopeptides of type II collagen(CTX-2)/U-Cre, Questionnaires about tablets | — |
Countries
Japan
Contacts
Public ContactYoshiko Yanagisawa
Kao Corporation Health Care Food Research Center
Outcome results
None listed