Pulmonary arterial hypertension Chronic thromboembolic pulmonary hyperetension
Conditions
Interventions
None listed
Sponsors
Graduated School of Medicine, Chiba University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who diagnosed as PAH or CTEPH in our institution.Inclusion criteia of patients were as follows. 1) adult patients (>20years old) 2) Mean pulmonary arterial pressure was above 25mmHg 3) Patients give written informed consents Healthy control subjects are recruited from staffs of our institution. Inclusion criteria of healthy control subjects are as follows. 1) adult patients (>20years old) 2) Patients give written informed consents
Exclusion criteria
Exclusion criteria: Exclusion criteria of PH patients or healthycontrol subjects are as follows. 1) uncontrolled diabetes mellitus 2) history of myocardial infarction 3) history of unstable angina pectoris 4) subjects with severe liver dysfunction (AST or ALT >150) 5) subjects with severe renal dysfunction (BUN >30mg/dl or Creatinine >2.0mg/dl) 6) pregnant female subjects 7) breast feeding female subjects 8) Exclusion by Investigators in safety
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Following endpoints were evaluated at diagnosis, 6, 12,24,36 months after starting treatments. 1) The composition of intestinal flora by 16S rRNA analysis 2) Functional analysis by meta-genome analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| Following endpoints were evaluated at diagnosis, 6, 12,24,36 months after starting treatments. 1) Right heart categorization 2) echocardiography 3) blood examination (BNP, UA, CRP) 4) fecal biochemistry (butyric acid, lactic acid) 5) analysis of oral flora 6) Physical activity | — |
Countries
Japan
Contacts
Public ContactTakayuki Jujo
Graduated School of Medicine, Chiba University Department of Advanced Medicine in Pulmonary Hypertension
Outcome results
None listed