None (Healthy adults)
Conditions
Interventions
Lactic acid bacteria, 1 portion of food per day for 8 weeks.
Placebo (not containing lactic acid bacteria), 1 portion of food per day for 8 weeks.
Sponsors
DeNA Life Science, Inc.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Males and females aged from 30 to less than 60 years old, when giving the informed consent. 2) Healthy individuals not having any chronic disedase or dermatoses. 3) Individuals who have skin problesms, such as acne. 4) Individuals who give the informed consents in writing, after receiving enough explanation of the purpose and details of the study, understanding the study well, and deciding to attend the study with their own will. 5) Individuals who can accomplish their tasks in the study at the appointed date. 6) Individuals who are judged suitable for this study by the investigators.
Exclusion criteria
Exclusion criteria: 1) Individuals who have diseases with medications. 2) Individuals who have continuously received medications within one month before the examination. 3) Individuals who have medical histories of serious disease of their liver, kidney, heart, lung, and blood. 4) Individuals who have comorbidity or medication history in their digestive organs. 5) Individuals whose systolic blood pressure is over 160 mmHg, or whose diastolic blood pressure is over 100 mmHg. 6) Individuals who have sever skin disorder. 7) Individuals who have severe anemia. 8) Individuals who might be allergic to test foods, or who might be seriously allergic to other foods, or medicaments. 9) Individuals who are pregnant, breastfeeding, or planning to be pregnant. 10) Individuals who are alcoholic or have mental disorder. 11) Individuals who will change their life style during the test period. 12) Individuals who have skin disease and need the application of medicine containing steroids or antibiotics to their face. 13) Individuals who have severe menopausal symptoms. 14) Individuals who cannot stop eating foods containing lactic acid bacteria. 15) Individuals who continuously took medicines for skin-condition-improvement within the last three month. 16) Individuals who use cosmetics that have strong effects on skin moisture or wrinkles. 17) Individuals who cannot keep from outdoor activities with the risk of getting sunburned during the test. 18) Individuals who had a surgery in their face within the past 6 months. 19) Individuals who are participating or participated in another clinical trial within the last 3 months. 20) Individuals who and whose family work for a company manufacturing or selling healthy foods, functional foods, and cosmetics. 21) Individuals who have smoking habitat. 22) Individuals who are judged unsuitable for this study by the investigator for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of skin microbiome (8 weeks) | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of skin condition by medical doctor (8 weeks) Analysis of expression level of skin-condition-related genes (8 weeks) Trans-epidermal water loss (8 weeks) Skin moisture content (8 weeks) VISIA skin analysis (8 weeks) Questionaries (4 weeks,8 weeks) | — |
Countries
Japan
Contacts
Public ContactTakashi Fujitomo
DeNA Life Science, Inc. Business Planning Dept.
Outcome results
None listed