Effect of dose timing of antihypertensive drug on blood pressure variability and target organ damage

Effect of dose timing of antihypertensive drug on blood pressure variability and target organ damage - TIMING study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025553

Enrollment

100

Registered

2017-01-11

Start date

2017-01-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

After getting an informed consent, patients are randamized into two groups (morning or evening). Controle 1 is morning group. After 6 mounts intervention, we will follow up the outcome for 7 years. A

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Hepertensive patients having antihypertensive drugs and over 135/85mmHg on morning blood pressure 2. Over 30 years old male and female

Exclusion criteria

Exclusion criteria: 1) Chronic kidney disease patients under hemodialysis 2) Other severe patients( ex: terminal cancer, active collagen disease) 3) alcohol abuser 4) drug abuser 5) disability of independent gait 6) patients who can not get informed consent from themselves 7) inappropriate patients judged by doctors

Design outcomes

Primary

Measure	Time frame
CAVI( Cardio Ankle Vascular Index) in 6 mounts after randamization	—

Secondary

Measure	Time frame
Variability of blood pressure Cardiovascular event	—

Countries

Japan

Contacts

Public ContactKei Sato

Mitsui Memorial Hospital Cardiology

m02045ks@jichi.ac.jp03-3862-9111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026