healthy person
Conditions
Interventions
administration of vonoprazan
Sponsors
National Hospital Organization Hakodate Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: (1)Healthy Japanese adult males. (2)Between the ages of 20-45 at the time of informed consent. (3)Subjects signed informed consent form voluntary.
Exclusion criteria
Exclusion criteria: (1)Subjects with history of gastric ulcer or duodenum ulcer (2)Subjects with a serious complication of liver failure (3)Subjects with a serious complication of renal failure (4)Subjects with a serious complication of heart failure (5)Subjects treated with atazanavir sulfate (Reyataz) or rilpivirine hydrochloride (Edurant) (6)Subjects with Zollinger-Ellison syndrome (7)Subjects with history of surgery that affects gastric-acid secretion (8)Subjects with a history of allergy to the investigational product (9)Subjects with atrophic gastritis, gastric tumor, gastric ulcer or duodenum ulcer by endoscopic examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gastric acid secretion (1day before administration, 6 days in administration, 3days after administration) | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum gastrin levels | — |
Countries
Japan
Contacts
Public ContactMototsugu Kato
National Hospital Organization Hakodate Hospital Department of Gastroenterology and Hepatology
Outcome results
None listed