major depressive disorder, persistent depressive disorder
Conditions
Interventions
The exercise bikes are used as exercise intervention for 30 min, twice a week, 16 weeks.
Sponsors
Hokkaido University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The participants are recruited from the outpatients at Hokkaido University Hospital, and diagnosed as major depressive disorder or persistent depressive disorder according to DSM-5.
Exclusion criteria
Exclusion criteria: 1. Patients with severe depression (HAM-D score 20 or more) 2. Patients expressing serious suicidal thoughts 3. Patients with YMRS score 13 or more 4. Patients with inflammatory disease 5. Patients with malignant tumor 6. Patients who can't take exercise using exercise bike due to orthopedic disease 7. Patients who have usually take exercise at fixed intervals 8. Patients treated with dialysis for chronic renal failure 9. patients whom principal investigators consider are not eligible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| amount of change in HAM-D before and 8,16 weeks after exercise sessions | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.amount of change in bech sub scale before and 8,16 weeks after exercise sessions 2.amount of change in CGI-S before and 8,16 weeks after exercise sessions 3.amount of change in BDI-2 before and 8,16 weeks after exercise sessions 4.amount of change in STAI before and 8,16 weeks after exercise sessions 5.amount of change in PSQI before and 8,16 weeks after exercise sessions 6.amount of change in SF-36v2 before and 8,16 weeks after exercise sessions 7.amount of change in SASS before and 8,16 weeks after exercise sessions 8.amount of change in cognitive function test before and 8,16 weeks after exercise sessions 9.amount of change in data for actigraphy and lifecoda before and 8,16 weeks after exercise sessions 10.amount of change in CPX before and 16 weeks after exercise sessions 11.amount of change in somatometry before and 16 weeks after exercise sessions 12.amount of change in biochemical marker in blood before and 16 weeks after exercise sessions 13.amount of change in function of PBMC mitochondria before and 16 weeks after exercise sessions 14.amount of change in biochemical marker in urine before and 16 weeks after exercise sessions15.assessment in relapse after 1 year | — |
Countries
Japan
Contacts
Public ContactShin Nakagawa
Hokkaido University Graduate School of Medicine Psychiatry
Outcome results
None listed