Efficacy of the assessment of ablative margin after radiofrequency ablation for hepatocellular carcinoma using magnetic resonance imaging with superparamagnetic iron oxide (SPIO)

Efficacy of the assessment of ablative margin after radiofrequency ablation for hepatocellular carcinoma using magnetic resonance imaging with superparamagnetic iron oxide (SPIO) - Efficacy of the assessment of ablative margin after RFA for HCC using MRI with SPIO

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025406

Enrollment

100

Registered

2016-12-26

Start date

2008-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

RFA is performed within 8hrs after SPIO-enhanced MRI. The ablative margin is evaluated with contrast-enhanced CT and non-enhanced MRI after 3days or later from RFA. Child-Pugh score of the patient

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hypervascular HCC (=< 3cm and =< 3 nodules) Detectable HCC by ultrasonography Capable of undergoing contrast-enhanced CT Capable of undergoing SPIO-enhanced MRI Child-Pugh grade: A or B

Exclusion criteria

Exclusion criteria: Massive ascites Undetectable HCC by SPIO-enhanced MRI

Design outcomes

Primary

Measure	Time frame
Local progression-free survival	—

Secondary

Measure	Time frame
Child-Pugh grade 6 months after RFA	—

Countries

Japan

Contacts

Public ContactKuniaki Fukuda

University of Tsukuba Gastroenterology

k-fukuda@md.tsukuba.ac.jp+81-29-853-3218

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026