The effect of fluid therapy on kidney function in hyperglycemIc emergencies. A multicenter retrospective study

Conditions

Hyperglycemic emergencies Diabetic ketoacidosis Hyperglycemic hyperosmolar syndrome

Takahashi K, Uenishi N, Sanui M, Uchino S, Yonezawa N, Takei T, Nishioka N, Kobayashi H, Otaka S, Yamamoto K, Yasuda H, Kosaka S, Tokunaga H, Fujiwara N, Kondo T, Ishida T, Komatsu T, Endo K, Moriyama T, Oyasu T, Hayakawa M, Hoshino A, Matsuyama T, Miyamoto Y, Yanagisawa A, Wakabayashi T, Ueda T, Komuro T, Sugimoto T, Sasabuchi Y.

2024-05-193 citations

10.1016/j.diabres.2024.111713

High versus low chloride load in adult hyperglycemic emergencies with acute kidney injury: a multicenter retrospective cohort study.

Takahashi K, Uenishi N, Sanui M, Uchino S, Yonezawa N, Takei T, Nishioka N, Kobayashi H, Otaka S, Yamamoto K, Yasuda H, Kosaka S, Tokunaga H, Fujiwara N, Kondo T, Ishida T, Komatsu T, Endo K, Moriyama T, Oyasu T, Hayakawa M, Hoshino A, Matsuyama T, Miyamoto Y, Yanagisawa A, Wakabayashi T, Ueda T, Komuro T, Sugimoto T, Sasabuchi Y.

2024-03-152 citations

10.1007/s11739-024-03556-0

Clinical profile of patients with diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome in Japan: a multicenter retrospective cohort study.

Takahashi K, Uenishi N, Sanui M, Uchino S, Yonezawa N, Takei T, Nishioka N, Kobayashi H, Otaka S, Yamamoto K, Yasuda H, Kosaka S, Tokunaga H, Fujiwara N, Kondo T, Ishida T, Komatsu T, Endo K, Moriyama T, Oyasu T, Hayakawa M, Hoshino A, Matsuyama T, Miyamoto Y, Yanagisawa A, Wakabayashi T, Ueda T, Komuro T, Sugimoto T, Lefor AK.

2023-09-207 citations

10.1007/s00592-023-02181-1

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Diagnosis of diabetic ketoacidosis or hyperglycemic hyperosmolar syndrome on admission

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Effect of the total amount of chloride in fluid administered within 48 hours of admission on the recovery of renal function in patients presenting with hyperglycemic emergencies complicated with AKI on admission.	—

Secondary

Measure	Time frame
Effect of the total amount of chloride in fluid on the incidence of AKI in patients without AKI on admission. The incidence, clinical characteristics (i.e, background type of diabetes, comorbidities, complications, provocating factors, complications, need for medical resources), and prognosis of diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome. Comparison of diagnostic yields of vital signs, white blood cell counts, C-reactive protein, and arterial blood gas analysis for the detection of infection in patients with hyperglycemic emergencies.	—

Measure

Time frame

Effect of the total amount of chloride in fluid on the incidence of AKI in patients without AKI on admission. The incidence, clinical characteristics (i.e, background type of diabetes, comorbidities, complications, provocating factors, complications, need for medical resources), and prognosis of diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome. Comparison of diagnostic yields of vital signs, white blood cell counts, C-reactive protein, and arterial blood gas analysis for the detection of infection in patients with hyperglycemic emergencies.

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Countries

Japan

Contacts

Public ContactNorimichi Uenishi

Fujita Health University Hospital Department of emergency and general internal medicine

uenishimd@yahoo.co.jp0562-93-2111

Outcome results