Food allergy
Conditions
Interventions
Cutaneous application of ovomucoid-containing hydrogel patch 12 hours a day for 48 weeks
Outaneous application of ovomucoid-containing hydrogel patch 12 hours a day for 24 weeks
Sponsors
National Hospital Organization Mie National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Egg allergy diagnosed by oral food challenge (OFC) without tendency of natural outgrow 2) Cooked egg dose threshold of OFC =<2g and underwent cutaneous application of ovomucoid-containing hydrogel patch or hydrogel patch without containing antigen for 24 weeks. 3)Cooked egg dose threshold of OFC =<2g after intervetion of 2).
Exclusion criteria
Exclusion criteria: 1) Allergy to soy and milk 2) Large change in intake levels of egg before 3 months of the trial 3) Complication or past history of heart, liver and kidney diseases 4) Uncontrolled asthma or atopic dermatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of dose threshold in oral egg challenge from 24 weeks to 48 weeks of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Change of dose threshold in oral egg challenge after 24 weeks of treatment 2.Safety:local reaction,systemic immediate-type allergic reaction and other 3.Prick test 4.Specific IgE and IgG4 5.Basophil activation test | — |
Countries
Japan
Contacts
Public ContactYu Kuwabara
National Hospital Organization Mie National Hospital Allergy center
Outcome results
None listed