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Research on the effect of a proton pump inhibitor on the oral and intestinal microbiota and salivary protein and metabolites.

Research on the effect of a proton pump inhibitor on the oral and intestinal microbiota and salivary protein and metabolites. - Influence of PPI on oral microbiota

Status
Unknown
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000025331
Enrollment
24
Registered
2016-12-20
Start date
2016-12-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteer

Interventions

None listed

Sponsors

Shimane university
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) over 20 year old 2) Informed consent about this research has been obtained with participants in writing form.

Exclusion criteria

Exclusion criteria: 1) daily usage of steroids, immunosuppresive and anticancer drugs 2) 20 or fewer teeth 3) using antibiotics during use or within 1 month 4) During pregnancy, lactating, a woman who may be pregnant 5) history of allergy to esomeprazole 6) A case of a history of resection of the gastrointestinal tract except for appendectomy 7) the research director judged inappropriate as the subject of this research

Design outcomes

Primary

MeasureTime frame
Ten adult healthy volunteers with no medications donated the fecal, saliva and periodontal pocket fluid samples before and after administration of esomeprazole 20mg once daily for 4 weeks. We then investigate the effect of PPIs on the bacterial communities using 16S rRNA gene sequencing method.—

Countries

Japan

Contacts

Public ContactTsuyoshi Mishiro

Shimane university school of medicine Division of gastroenterology

tmishiro@med.shimane-u.ac.jp0853-20-2190

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026